Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	114997
Country	Greece

Category	Surgery
Manuscript Type	Review
Article Title	Protective effect of ischemic preconditioning against hepatic ischemia-reperfusion injury and associated remote organ damage
Manuscript Source	Invited Manuscript
All Author List	Christina Mouratidou, Efstathios T Pavlidis, Georgios Katsanos, Serafeim-Chrysovalantis Kotoulas, Athanasios Kofinas, Alexandra G Marneri, Eleni Massa, Georgios Tsoulfas, Ioannis N Galanis and Theodoros E Pavlidis
Funding Agency and Grant Number
Corresponding Author	Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Key Words	Hepatic ischemia-reperfusion injury; Remote organ damage; Systemic inflammatory response; Ischemic preconditioning; Liver transplantation; Protective method; Pathophysiological mechanisms
Core Tip	Hepatic ischemia-reperfusion injury remains a critical challenge in liver surgery and transplantation and results in increased postoperative morbidity and mortality. The complexity of the underlying pathophysiological mechanisms makes liver damage difficult to manage. Ischemic preconditioning is a promising protective strategy that limits hepatic injury while providing systemic benefits through the regulation of oxidative stress, the inflammatory response, and programmed cell death pathways. By offering protection to remote organs, ischemic preconditioning has the potential to enhance the outcomes of transplantation and other high-risk procedures, although further studies are needed to establish optimal clinical protocols.
Citation	Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Kofinas A, Marneri AG, Massa E, Tsoulfas G, Galanis IN, Pavlidis TE. Protective effect of ischemic preconditioning against hepatic ischemia-reperfusion injury and associated remote organ damage. World J Gastrointest Surg 2025; In press

Received	2025-10-09 17:11
Peer-Review Started	2025-10-09 17:11
First Decision by Editorial Office Director	2025-11-05 05:58
Return for Revision	2025-11-05 05:58
Revised	2025-11-06 10:38
Publication Fee Transferred
Second Decision by Editor	2025-12-05 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-05 09:44
Articles in Press	2025-12-05 09:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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