Publication Name	World Journal of Gastroenterology
Manuscript ID	115009
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Molecular profiling-directed individualized adjuvant therapy in colorectal cancer: Bridging consensus guidelines to clinical disparities
Manuscript Source	Invited Manuscript
All Author List	Xiao-Fei Cheng
Funding Agency and Grant Number
Corresponding Author	Xiao-Fei Cheng, Associate Chief Physician, MD, PhD, Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Raod, Hangzhou 310003, Zhejiang Province, China. xfcheng@zju.edu.cn
Key Words	Colorectal cancer; Adjuvant therapy; Molecular subtyping; Consensus molecular subtypes; Circulating tumor DNA; Precision medicine
Core Tip	Molecular profiling, including mismatch repair deficiency/microsatellite instability, circulating tumor DNA (ctDNA), and consensus molecular subtypes, refines risk stratification and guides personalized adjuvant therapy in colorectal cancer. Persistent gaps between guidelines and practice stem from technical variability, limited evidence for novel strategies (e.g., ctDNA-guided escalation), and health economic disparities. Bridging these requires integrated artificial intelligence-multiomics decision tools, dynamic ctDNA monitoring, and health policy reforms supporting equitable implementation.
Citation	Cheng XF. Molecular profiling-directed individualized adjuvant therapy in colorectal cancer: Bridging consensus guidelines to clinical disparities. World J Gastroenterol 2025; In press

Received	2025-10-09 16:12
Peer-Review Started	2025-10-09 16:12
First Decision by Editorial Office Director	2025-11-06 09:30
Return for Revision	2025-11-06 09:30
Revised	2025-11-14 12:54
Publication Fee Transferred
Second Decision by Editor	2025-12-19 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-19 09:14
Articles in Press	2025-12-19 09:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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