Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115010
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Microbiota-metabolite signatures in metastatic colorectal cancer: Promise, pitfalls, and the path forward
Manuscript Source	Invited Manuscript
All Author List	Ting-Ting Zhang, Juan Yao and Han-Meng Zhang
Funding Agency and Grant Number
Corresponding Author	Han-Meng Zhang, MD, Department of Oncology, Huai’an Hospital of Huai’an City, No. 19 Shanyang Avenue, Huai’an 223299, Jiangsu Province, China. 15380666158@163.com
Key Words	Colorectal cancer; Gut microbiota; Metastasis; Metabolomics; 16S rRNA sequencing; Microbial diversity; Differential metabolites; Cancer progression; Metabolic pathways; Diagnostic biomarkers
Core Tip	Deng et al explores the role of gut microbiota and metabolites in colorectal cancer (CRC) metastasis using 16S rRNA sequencing and liquid chromatography-mass spectrometry-based metabolomics. It identifies significant differences in microbial communities and metabolites between metastatic and non-metastatic CRC patients. The findings suggest that specific microbial taxa and metabolites may contribute to metastasis progression, offering potential biomarkers for diagnosis and treatment. Despite some limitations, such as small sample size and cross-sectional design, the study provides valuable insights into the microbiota-metabolite axis and its potential for therapeutic targeting in CRC.
Citation	Zhang TT, Yao J, Zhang HM. Microbiota-metabolite signatures in metastatic colorectal cancer: Promise, pitfalls, and the path forward. World J Gastrointest Oncol 2025; In press

Received	2025-10-09 02:51
Peer-Review Started	2025-10-09 02:51
To Make the First Decision
Return for Revision	2025-10-28 09:43
Revised	2025-11-05 08:05
Second Decision	2025-11-27 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-27 07:55
Articles in Press	2025-11-27 07:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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