Publication Name	World Journal of Cardiology
Manuscript ID	115016
Country	Italy

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Letter to the Editor
Article Title	Frailty in elderly patients with non-ST elevation myocardial infarction: Balancing the risks and benefits of percutaneous coronary intervention
Manuscript Source	Invited Manuscript
All Author List	Hussam Ali, Flavio Airoldi and Riccardo Cappato
Funding Agency and Grant Number
Corresponding Author	Hussam Ali, Arrhythmia and Electrophysiology Center, IRCCS MultiMedica, Via Milanese 300, Sesto San Giovanni 20099, Milan, Italy. hussamali.ep@gmail.com
Key Words	Frailty; Non-ST elevation myocardial infarction; Percutaneous coronary intervention; Personalised care, Letter to editor
Core Tip	Frailty is increasingly recognized as a key determinant of outcomes in elderly patients with non-ST elevation myocardial infarction, yet its role in guiding invasive management remains debated. The recent analysis by Popat et al suggests that percutaneous coronary intervention may confer survival benefit across frailty categories, while also exposing patients to higher risks of complications, longer hospitalizations, and greater costs. These findings highlight the complexity of decision-making in this vulnerable cohort. In this letter to the editor, we reflect on these results and discuss them in the context of current literature, practice guidelines, and future directions.
Citation	Ali H, Airoldi F, Cappato R. Frailty in elderly patients with non-ST elevation myocardial infarction: Balancing the risks and benefits of percutaneous coronary intervention. World J Cardiol 2025; In press

Received	2025-10-09 15:48
Peer-Review Started	2025-10-09 15:48
First Decision by Editorial Office Director	2025-10-23 08:26
Return for Revision	2025-10-23 08:26
Revised	2025-11-07 01:15
Publication Fee Transferred
Second Decision by Editor	2025-12-22 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 07:30
Articles in Press	2025-12-22 07:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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