Publication Name	World Journal of Diabetes
Manuscript ID	115021
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Letter to the Editor
Article Title	RRM2 attenuates renal tubular ferroptosis in diabetic kidney disease through the PI3K/Akt/Nrf2 pathway: Strengths, limitations, and future research directions
Manuscript Source	Invited Manuscript
All Author List	Ying-Chun Liu, Jing Xiao and Lin Chen
Funding Agency and Grant Number
Corresponding Author	Lin Chen, Director, MD, PhD, Department of Ultrasound, Huadong Hospital, Fudan University, West Yan'an Road 221, Shanghai 200040, China. cl_point@126.com
Key Words	Type 2 diabetes mellitus; Diabetic nephropathy; Ribonucleotide reductase regulatory subunit M2; Oxidative stress; Ferroptosis; PI3K/Akt pathway; Renal tubular cells
Core Tip	Against the backdrop of challenges in early diagnosis and preventing the progression of diabetic kidney disease (DKD), with the key molecules involved in its related mechanisms remaining unclear, this study confirms the protective effect of ribonucleotide reductase M2 on DKD. Its protective effect shows a certain relevance to DKD research.
Citation	Liu YC, Xiao J, Chen L. RRM2 attenuates renal tubular ferroptosis in diabetic kidney disease through the PI3K/Akt/Nrf2 pathway: Strengths, limitations, and future research directions. World J Diabetes 2025; In press

Received	2025-10-10 01:13
Peer-Review Started	2025-10-10 10:24
First Decision by Editorial Office Director	2025-10-29 08:16
Return for Revision	2025-10-29 08:16
Revised	2025-11-10 14:40
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 03:41
Articles in Press	2025-12-15 03:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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