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Articles in Press
1/14/2026 8:46:39 AM | Browse: 1 | Download: 0
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Goosecoid drives colorectal cancer progression by inducing epithelial-mesenchymal transition
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bai-Chao Li, Bing-Zhe Wang, Liang Han, Zhi-Wei Zhang, Ying Wang, Yong-Jian Zhang and Jiu-Na Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Hebei Province (General Program) |
No. H2022402009 |
| Precision Medicine Joint Cultivation Fund Project of Hebei Natural Science Foundation |
No. H2021402007 |
| Hebei Provincial Department of Finance |
No. ZF2023221 |
| Cooperative Project of the Affiliated Hospital of Hebei University of Engineering |
No. KFKT2024-05 |
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| Corresponding Author |
Jiu-Na Zhang, PhD, Department of Gastroenterology, The Affiliated Hospital of Hebei University of Engineering, No. 81 Congtai Road, Handan 056002, Hebei Province, China. zhangjiuna@hebeu.edu.cn |
| Key Words |
Colorectal cancer; Goosecoid; Epithelial-mesenchymal transition; Invasion; Metastasis; Wnt/β-catenin |
| Core Tip |
Goosecoid (GSC) is significantly upregulated in colorectal cancer (CRC) tissues and cell lines, with its elevated expression correlated with unfavorable patient outcomes. Functional analyses demonstrate that GSC knockdown attenuates CRC cell proliferation, migration, and invasion. Mechanistically, these inhibitory effects are mediated through the Wnt/β-catenin signaling pathway, concomitant with the regulation of key epithelial-mesenchymal transition markers. Collectively, our findings establish GSC as a critical promoter of CRC growth and metastatic dissemination. |
| Citation |
Li BC, Wang BZ, Han L, Zhang ZW, Wang Y, Zhang YJ, Zhang JN. Goosecoid drives colorectal cancer progression by inducing epithelial-mesenchymal transition. World J Gastrointest Oncol 2026; In press |
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Received |
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2025-10-11 15:53 |
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Peer-Review Started |
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2025-10-11 15:53 |
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First Decision by Editorial Office Director |
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2025-11-14 02:24 |
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Return for Revision |
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2025-11-14 02:24 |
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Revised |
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2025-11-24 11:47 |
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Publication Fee Transferred |
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2025-11-28 04:13 |
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Second Decision by Editor |
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2026-01-14 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-14 08:46 |
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Articles in Press |
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2026-01-14 08:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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