Publication Name	World Journal of Diabetes
Manuscript ID	115033
Country	India

Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	Molecular insights into hyperglycemia-associated coronary heart disease: From glycemic variability and heart rate dynamics to long noncoding RNAs
Manuscript Source	Invited Manuscript
All Author List	Shilpy Singh, Varun Kumar Sharma and Dharmsheel Shrivastav
Funding Agency and Grant Number
Corresponding Author	Dharmsheel Shrivastav, Assistant Professor, PhD, Department of Biotechnology, Microbiology and Forensic Sciences, School of Sciences, Noida International University, Plot 1, Yamuna Expy, Sector 17A, Greater Noida 203201, Uttar Pradesh, India. dharmsheel.shrivastav1@gmail.com
Key Words	Long non-coding RNA; Transcription factor; Diabetes mellitus; Coronary artery disease; Glycemic variability
Core Tip	The retrospective study by Li et al highlights the interplay between glycemic variability and heart rate dynamics in elderly patients with type 2 diabetes and coronary heart disease. It demonstrates that combining glucose excursion markers surpasses traditional heart rate variability indices in predicting myocardial ischemia. Emerging evidence implicates lncRNA PSMB8-AS-1 and transcription factor triads (PSMB9/ZEB-1/NONO) in linking inflammation and vascular instability to acute coronary syndromes. These findings support integrating dynamic glucose monitoring with molecular biomarker profiling to enhance precision cardiovascular risk stratification in diabetic patients.
Citation	Singh S, Sharma VK, Shrivastav D. Molecular insights into hyperglycemia-associated coronary heart disease: From glycemic variability and heart rate dynamics to long noncoding RNAs. World J Diabetes 2025; In press

Received	2025-10-09 00:15
Peer-Review Started	2025-10-10 00:07
First Decision by Editorial Office Director	2025-11-11 07:49
Return for Revision	2025-11-11 07:49
Revised	2025-11-20 09:56
Publication Fee Transferred
Second Decision by Editor	2025-12-17 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 12:41
Articles in Press	2025-12-17 12:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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