Publication Name	World Journal of Nephrology
Manuscript ID	115039
Country	France

Category	Biology
Manuscript Type	Minireviews
Article Title	Effects of micro and nano plastics on renal health
Manuscript Source	Invited Manuscript
All Author List	Jean Demarquoy
Funding Agency and Grant Number
Corresponding Author	Jean Demarquoy, PhD, Université de Bourgogne Europe, Institut Agro-INRAe, 6 blvd Gabriel, Dijon 21000, France. jean.demarquoy@u-bourgogne.fr
Key Words	Microplastics; Kidney; Nephrotoxicity; Ferroptosis; Pyroptosis; Oxidative stress; Co-exposure; Dialysis; Environmental health
Core Tip	Microplastics and nanoplastics are emerging environmental contaminants capable of reaching the human kidney through ingestion, inhalation, and medical exposure. Experimental data reveal that microplastics accumulate in renal tissue, inducing oxidative stress, endoplasmic reticulum stress, inflammation, autophagy, and ferroptosis. Co-exposure with metals or plastic additives enhances nephrotoxicity, while early human findings confirm their presence in kidney tissue and dialysis fluids. This review integrates mechanistic, experimental, and clinical evidence, highlighting the kidney as a vulnerable target organ and calling for standardized detection methods, multi-omics approaches, and biomonitoring to assess the health burden of plastic exposure.
Citation	Demarquoy J. Effects of micro and nano plastics on renal health. World J Nephrol 2026; In press

Received	2025-10-09 17:09
Peer-Review Started	2025-10-09 17:09
First Decision by Editorial Office Director	2025-10-21 07:39
Return for Revision	2025-10-21 07:39
Revised	2025-10-27 20:32
Publication Fee Transferred
Second Decision by Editor	2026-01-07 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-07 09:49
Articles in Press	2026-01-07 09:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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