Publication Name	World Journal of Gastroenterology
Manuscript ID	115044
Country	India

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Refining early detection of hepatocellular carcinoma: The promise of the GALAD score
Manuscript Source	Invited Manuscript
All Author List	Harsha S P, Amit Sehrawat, Anusha Mruthyunjaya Swamy and Deepak Sundriyal
Funding Agency and Grant Number
Corresponding Author	Amit Sehrawat, Department of Medical Oncology Haematology, All India Institute of Medical Sciences, Virbhadra Road, Rishikesh 249203, Uttarakhand, India. dramitsehrawat@gmail.com
Key Words	Hepatocellular carcinoma; GALAD score; Alpha-fetoprotein; Des-gamma-carboxy prothrombin; Early detection; Biomarker algorithms; Liver cancer surveillance
Core Tip	Compared to alpha-fetoprotein (AFP) and ultrasonography alone, the GALAD score, which takes into account age, sex, AFP, AFP-L3, and des-gamma-carboxy prothrombin, shows superior diagnostic effectiveness for hepatocellular carcinoma. However, different groups have different best cut-offs, which supports the idea that a global criterion is inappropriate. Future multi-ethnic prospective studies and integration with imaging (e.g., GALADUS) are necessary for the standardized, cost-effective detection of early hepatocellular carcinoma.
Citation	Harsha SP, Sehrawat A, Swamy AM, Sundriyal D. Refining early detection of hepatocellular carcinoma: The promise of the GALAD score. World J Gastroenterol 2025; In press

Received	2025-10-20 01:49
Peer-Review Started	2025-10-20 01:50
First Decision by Editorial Office Director	2025-11-19 10:42
Return for Revision	2025-11-19 10:42
Revised	2025-11-28 14:22
Publication Fee Transferred
Second Decision by Editor	2025-12-19 02:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-19 09:28
Articles in Press	2025-12-19 09:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com