Publication Name	World Journal of Hepatology
Manuscript ID	115048
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Current management strategies for sarcopenia and frailty in cirrhosis: Missing link in transplant candidacy
Manuscript Source	Invited Manuscript
All Author List	Manjeet Kumar Goyal, Rishi Chowdhary, Chirag Vohra, Megh Patel, Shivam Kalra, Madhav Mehta, Rachel McNulty, Kartikay Goyal, Ashita Rukmini Vuthaluru and Omesh Goyal
Funding Agency and Grant Number
Corresponding Author	Omesh Goyal, Professor, Department of Gastroenterology, Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana 141001, Punjab, India. dromeshgoyal@gmail.com
Key Words	Cirrhosis; Sarcopenia; Frailty; Liver transplant; Malnutrition; Hyperammonemia; Exercise therapy; Branched-chain amino acids
Core Tip	Sarcopenia and frailty are underrecognized yet powerful predictors of outcomes in cirrhosis, influencing decompensation, hospitalizations, transplantation waitlist dropout, and post-transplant survival independent of the model for end-stage liver disease score. Simple bedside tools such as handgrip strength, chair stands, gait speed, and the Liver Frailty Index as well as imaging-based skeletal muscle measures enable early recognition. Incorporating routine assessment and structured prehabilitation, including adequate nutrition, resistance and aerobic exercise, and management of cirrhosis complications, can improve quality of life, reduce adverse outcomes, and optimize transplant candidacy.
Citation	Goyal MK, Chowdhary R, Vohra C, Patel M, Kalra S, Mehta M, McNulty R, Goyal K, Vuthaluru AR, Goyal O. Current management strategies for sarcopenia and frailty in cirrhosis: Missing link in transplant candidacy. World J Hepatol 2025; In press

Received	2025-10-10 06:52
Peer-Review Started	2025-10-10 06:52
To Make the First Decision
Return for Revision	2025-11-05 08:05
Revised	2025-11-17 14:44
Second Decision	2025-11-25 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-26 10:09
Articles in Press	2025-11-26 10:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-11-27 10:58
Typeset the Manuscript

ISSN	1948-5182 (online)
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