Publication Name	World Journal of Virology
Manuscript ID	115071
Country	Sri Lanka

Category	Virology
Manuscript Type	Retrospective Study
Article Title	Detection of dengue virus encephalitis in central part of Sri Lanka
Manuscript Source	Invited Manuscript
All Author List	Inuri Perera, Achini Weerathunga, Nipuni Arachchige, Lakmali Rajamanthri, Sachini Fernando and Rohitha Muthugala
Funding Agency and Grant Number
Corresponding Author	Rohitha Muthugala, Consultant, MD, Department of Molecular Biology, Medical Research Institute, No. 527 Dr. Danister De Silva Mawatha, Colombo 00800, Western, Sri Lanka. rohithavm@yahoo.com
Key Words	Flavivirus; Central nervous system infections; Neurotropic viruses; Dengue; Sri Lanka
Core Tip	Encephalitis due to arbovirus infections is a significant public health problem in tropical Asia. Encephalitis is caused by wide range of neurotropic pathogens, and flaviviruses are one of the main causative agents in tropics. Sri Lanka reports a considerable number of central nervous system infections annually. Both dengue and Japanese encephalitis are endemic, and cases of Zika and West Nile virus infections were reported in Sri Lanka. This study describes dengue virus (DENV) infections in clinically suspected patients with encephalitis in the central part of the country. A retrospective observational analysis was conducted on 99 cerebrospinal fluid samples. One sample was positive for dengue serotype 3 RNA and five samples were positive for dengue immunoglobulin M indicating recent DENV infections. These findings highlight the presence of DENV central nervous system infections and emphasize the need for broader surveillance and advanced diagnostics in future.
Citation	Perera I, Weerathunga A, Arachchige N, Rajamanthri L, Fernando S, Muthugala R. Detection of dengue virus encephalitis in central part of Sri Lanka. World J Virol 2025; In press

Received	2025-10-13 07:30
Peer-Review Started	2025-10-13 07:30
First Decision by Editorial Office Director	2025-11-14 07:02
Return for Revision	2025-11-14 07:02
Revised	2025-11-19 15:38
Publication Fee Transferred
Second Decision by Editor	2025-12-11 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-11 09:07
Articles in Press	2025-12-11 09:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3249 (online)
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