Publication Name	World Journal of Gastroenterology
Manuscript ID	115077
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Xing-Pi-Qing-Gan decoction alleviates alcoholic liver disease by down-regulating DDIT3 and restoring Nrf2/HO-1 antioxidant signaling: Multi-omics and experimental evidence
Manuscript Source	Unsolicited Manuscript
All Author List	Na-Fei Huang, Ping Ling, Yu-Jie Xu, Xiao-Feng Feng, Yi Zheng and Tao Sun
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang Province ZCLQN25H2703 Zhejiang TCM Science and Technology Plan 2025ZR126 the Science and Technology Department of the National Administration of Traditional Chinese Medicine - Administration of Traditional Chinese Medicine of Zhejiang Province Jointly Established Science and Technology Plan Project GZY-ZJ-KJ-24071
Corresponding Author	Tao Sun, Associate Chief Physician, MD, The Second Affiliated Hospital of Zhejiang Chinese Medical University, The Second Affiliated Hospital of Zhejiang Chinese Medical University, The Second Affiliated Hospital of Zhejiang Chinese Medical University, No. 318, Chaowang Road, Gongshu Distric, Hangzhou, Hangzhou 310005, Zhejiang Province, China. 20171075@zcmu.edu.cn
Key Words	Alcoholic liver disease; Xing-Pi-Qing-Gan decoction; DDIT3; Nrf2/HO-1; Oxidative stress
Core Tip	Xing-Pi-Qing-Gan decoction (XPQG) is effective in improving ethanol-induced acute liver injury. XPQG alleviates alcoholic liver disease by suppressing DDIT3 and enhancing Nrf2/HO-1-mediated antioxidant responses, reduce lipid accumulation, inflammation, and apoptosis, as validated through multi-omics and experimental studies.
Citation	Huang NF, Ling P, Xu YJ, Feng XF, Zheng Y, Sun T. Xing-Pi-Qing-Gan decoction alleviates alcoholic liver disease by down-regulating DDIT3 and restoring Nrf2/HO-1 antioxidant signaling: Multi-omics and experimental evidence. World J Gastroenterol 2025; In press

Received	2025-10-15 08:57
Peer-Review Started	2025-10-15 08:58
First Decision by Editorial Office Director	2025-11-11 09:53
Return for Revision	2025-11-11 09:53
Revised	2025-11-24 11:51
Publication Fee Transferred	2025-11-26 04:24
Second Decision by Editor	2025-12-12 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-12 07:29
Articles in Press	2025-12-12 07:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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