Publication Name	World Journal of Critical Care Medicine
Manuscript ID	115099
Country	Pakistan

Category	Critical Care Medicine
Manuscript Type	Observational Study
Article Title	Sex differences in serious outcomes among critically ill adults following endotracheal intubation
Manuscript Source	Invited Manuscript
All Author List	Shahan Waheed, Sajid Ali, Nadeemullah Khan, Ahmed Raheem and Sarah Afzal Kothari
Funding Agency and Grant Number
Corresponding Author	Sajid Ali, Chief Physician, Postdoc, Department of Emergency Medicine, Aga Khan University and Hospital, Stadium Road, Karachi 74800, Sindh, Pakistan. sajid.mubarak@aku.edu
Key Words	Sex; Serious outcomes; Emergency medicine; Airway; Predictors; Endotracheal intubation
Core Tip	This study explores sex-based differences in outcomes following endotracheal intubation in critically ill adults in the emergency department. Although overall complication rates were comparable between men and women, females demonstrated a higher incidence of post-intubation hypotension, even after adjustment for baseline clinical factors. This suggests that sex-related physiological differences may influence hemodynamic responses during airway management. The findings underscore the importance of recognizing sex as a potential risk modifier and highlight the need for tailored, sex-specific strategies to improve safety and optimize outcomes in critically ill patients undergoing intubation.
Citation	Waheed S, Ali S, Khan N, Raheem A, Kothari SA. Sex differences in serious outcomes among critically ill adults following endotracheal intubation World J Crit Care Med 2026; In press

Received	2025-10-13 08:33
Peer-Review Started	2025-10-13 08:33
First Decision by Editorial Office Director	2025-10-22 08:47
Return for Revision	2025-10-22 08:47
Revised	2025-11-05 06:48
Publication Fee Transferred
Second Decision by Editor	2026-02-12 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-12 07:07
Articles in Press	2026-02-12 07:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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