Publication Name	World Journal of Critical Care Medicine
Manuscript ID	115116
Country	India

Category	Critical Care Medicine
Manuscript Type	Editorial
Article Title	Brain-kidney cross-talk: A call for action!
Manuscript Source	Invited Manuscript
All Author List	Susan Paulin and Ratthinam Palaniappan
Funding Agency and Grant Number
Corresponding Author	Susan Paulin, Consultant, Department of Liver Transplant Anaesthesia and Critical Care, Dr Rela Institute and Medical Centre, No. 7 CLC works road, Nagappa Nagar, Chennai 600044, Tamil Nādu, India. susanvercetti@gmail.com
Key Words	Brain-kidney; Acute kidney injury in traumatic brain injury; Biomarkers in traumatic brain injury; Renal replacement in traumatic brain injury; Artificial intelligence-based prediction models
Core Tip	Optimal management of traumatic brain injury requires moving beyond immediate neurological threats to address profound systemic complications that often determine patient outcome. The critical question remains: Does identification of predictors translate into effective prevention? A call for action is needed in refining hemodynamic targets, utilization of advanced hemodynamic monitoring, exploring predictive biomarkers, and developing Artificial Intelligence-based prediction models. Clinical focus must expand beyond the immediate neurological threats to address the full spectrum of traumatic brain injury pathophysiology to develop integrated, multi-organ therapeutic strategies and enhance patient outcomes with efficient resource utilization.
Citation	Paulin S, Palaniappan R. Brain-kidney cross-talk: A call for action!. World J Crit Care Med 2026; In press

Received	2025-10-09 02:09
Peer-Review Started	2025-10-09 02:09
First Decision by Editorial Office Director	2025-11-21 09:50
Return for Revision	2025-11-21 09:50
Revised	2025-12-09 05:41
Publication Fee Transferred
Second Decision by Editor	2026-01-19 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-19 04:05
Articles in Press	2026-01-19 04:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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