Publication Name	World Journal of Gastroenterology
Manuscript ID	115120
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Revisiting HLA-DQA1*05 in Asian inflammatory bowel disease cohorts: Ethnic variations in genetic susceptibility to immunogenicity
Manuscript Source	Invited Manuscript
All Author List	Chao-Qun Hu, Xiao-Mei Song, Yong-Sheng Teng and Hong Guo
Funding Agency and Grant Number	Funding Agency Grant Number the Science and Health Joint Medical Research Program of Chongqing Municipality 2024ZDXM009
Corresponding Author	Hong Guo, Professor, Department of Gastroenterology, Chongqing General Hospital, Chongqing University, No. 118 Xingguang Avenue, Liangjiang New Area, Chongqing 401147, China. hguo_cgh2021@163.com
Key Words	Inflammatory bowel disease; Anti-tumor necrosis factor therapy; Anti-drug antibodies; Human leukocyte antigen genotype; Ethnic variation
Core Tip	This letter builds upon Weng et al’s study in Taiwan that incorporated comparative evidence from Asia and Europe toward the investigation of racial disparities in human leukocyte antigen (HLA)-related immunogenicity of anti-tumor necrosis factor therapy. Although Weng et al did not identify an association between HLA-DQA1*05 and the development of anti-drug antibody against infliximab and adalimumab, other larger-scale studies across Chinese and European cohorts demonstrated a significant correlation between HLA-DQA1*05 and anti-drug antibody formation, particularly with infliximab, highlighting the genetic diversity within Asia. The novel alleles reported by Weng et al warrant further validation. Until further comprehensive, large-scale racial cohort data becomes available, clinicians should prioritize therapeutic drug monitoring and individualized treatment approaches. Furthermore, HLA allele screening for inflammatory bowel disease treatment decisions requires support from larger, genetically diverse cohort studies.
Citation	Hu CQ, Song XM, Teng YS, Guo H. Revisiting HLA-DQA1*05 in Asian inflammatory bowel disease cohorts: Ethnic variations in genetic susceptibility to immunogenicity. World J Gastroenterol 2025; In press

Received	2025-10-09 16:03
Peer-Review Started	2025-10-09 16:03
First Decision by Editorial Office Director	2025-11-14 09:20
Return for Revision	2025-11-14 09:20
Revised	2025-11-24 14:13
Publication Fee Transferred
Second Decision by Editor	2025-12-16 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 09:16
Articles in Press	2025-12-16 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com