Publication Name	World Journal of Gastroenterology
Manuscript ID	115130
Country	Czech Republic

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Jing Ye, Esraa Ali, Sergii Pavlov, Lenka Červenková, Filip Ambrozkiewicz, Ondřej Vyčítal, Petr Hošek, František Zitrický, Ondřej Daum, Václav Liška, Kari Hemminki and Andriy Trailin
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Health of Czech Republic No. NU21-03-00506 Czech National Institute for Cancer Research No. LX22NPO5102
Corresponding Author	Andriy Trailin, MD, PhD, Senior Researcher, Laboratory of Translational Cancer Genomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1665/76, Pilsen 32300, Czech Republic. andriy.trailin@lfp.cuni.cz
Key Words	Macrophages; Primary colorectal cancer; Adjacent nontumor mucosa; Liver metastases; Survival
Core Tip	Limited evidence exists regarding the distribution and prognostic associations of different subsets of macrophages in colorectal cancer (CRC) and adjacent nontumor mucosa (NM) in patients stage IV with synchronous liver metastases or stage I-III who developed metachronous liver metastases thereafter. This retrospective cohort study included 55 stage IV and 44 stage I-III patients. M2-macrophages outnumbered M1 and M0 both in primary CRC and NM with significantly reduced cell densities in tumor tissue. Greater density of M1 macrophages is a hallmark of NM in stage I-III CRC. Higher densities of macrophages in NM demonstrate favorable associations with survival.
Citation	Ye WJ, Ali E, Pavlov S, Červenková L, Ambrozkiewicz F, Vyčítal O, Hošek P, Zitrický F, Daum O, Liška V, Hemminki K, Trailin A. Distribution and prognostic value of macrophages in colorectal cancer and adjacent mucosa in patient stages I-III vs IV. World J Gastroenterol 2026; In press

Received	2025-10-13 14:18
Peer-Review Started	2025-10-13 14:18
First Decision by Editorial Office Director	2025-11-10 07:58
Return for Revision	2025-11-10 07:58
Revised	2025-11-20 18:39
Publication Fee Transferred
Second Decision by Editor	2026-01-08 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-08 10:03
Articles in Press	2026-01-08 10:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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