Publication Name	World Journal of Gastroenterology
Manuscript ID	115143
Country	China

Category	Microbiology
Manuscript Type	Basic Study
Article Title	Candida-mediated vertical transmission of Helicobacter pylori in C57BL/6J mice
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Li Xu, Ting-Ting Luo, Qi Liu, Gu-Zhen Cui, Dao-Yan Wu, Xiao-Juan Wu, Ting-Xiu Yang, Jian-Chao Sun, Hui-Feng Jian, Shu-Wei Zhuo and Zheng-Hong Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Science Foundation of China 82260402 Research Foundation of The Affiliated Hospital of Guizhou Medical University GYFYMF002 Central-Guided Local Science and Technology Projects of Guizhou Province Qiankehe [2025] 024 Guizhou Key Laboratory ZDSYS[2023]004 Guizhou Provincial Key Laboratory for Digestive System Diseases ZSYS[2025]021 Basic Research Program of Guizhou Science and Technology Plan ZK[2022]341 National Science Foundation of Hainan 82QN0993 Research Foundation of The Affiliated Hospital of Guizhou Medical University GYFYMF001 Basic Research Program of Guizhou Science and Technology Plan ZK[2022]368
Corresponding Author	Zheng-Hong Chen, PhD, Professor, Guizhou Key Laboratory of Microbio and Infectious Disease Prevention and Control, Guizhou Medical University, No. 6 Ankang Avenue, Gui’an New Area 561113, Guizhou Province, China. chenzhenghong@gmc.edu.cn
Key Words	Helicobacter pylori; Candida; Internalization; Reservoir; Vertical transmission
Core Tip	A comprehensive understanding of the familial pathway for Helicobacter pylori (H. pylori) transmission is essential for establishing effective infection prevention and control measures. However, the route through which this pathogen is transmitted remains unclear. Our preliminary findings had revealed that H. pylori can internalize within Candida cells, and that maternal vaginal colonization of Candida may serve as a potential route for transmission to neonates during childbirth. On the basis of animal experiments, we seek to confirm the transmission of H. pylori-positive Candida from maternal mice to their offspring during birth, potentially leading to H. pylori infection in the offspring.
Citation	Xu XL, Luo TT, Liu Q, Cui GZ, Wu DY, Wu XJ, Yang TX, Sun JC, Jian HF, Zhuo SW, Chen ZH. Candida-mediated vertical transmission of Helicobacter pylori in C57BL/6J mice. World J Gastroenterol 2025; In press

Received	2025-10-14 04:50
Peer-Review Started	2025-10-14 04:50
First Decision by Editorial Office Director	2025-10-28 10:11
Return for Revision	2025-10-28 10:11
Revised	2025-11-10 15:23
Publication Fee Transferred	2025-11-11 13:21
Second Decision by Editor	2025-12-16 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 07:30
Articles in Press	2025-12-16 07:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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