Publication Name	World Journal of Gastroenterology
Manuscript ID	115162
Country	China

Category	Medical Informatics
Manuscript Type	Prospective Study
Article Title	Predicting gastrointestinal bleeding and audio biomarkers based on machine learning analysis of bowel sounds
Manuscript Source	Unsolicited Manuscript
All Author List	Lei Zhang, Meng-Yue Wang, Shi-Yu Wei, Cheng Su, Sen-Yi Hu, Xiao-Yang Ren, Ya-Ping Liu, Chang Liu and Yong Wan
Funding Agency and Grant Number	Funding Agency Grant Number Key Project of Shaanxi Provincial Natural Science Basic Research Program 2024JC-ZDXM-49 The Integration of Basic Shaanxi Wisdom Medical Common Technology Platform 2023GXJS-01
Corresponding Author	Yong Wan, MD, Department of Geriatric Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 West Yanta Road, Xi’an 710061, Shaanxi Province, China. docwanyong@xjtu.edu.cn
Key Words	Bowel sound analysis; Upper gastrointestinal bleeding; Support vector machine; Machine learning; Non-invasive diagnosis
Core Tip	This study develops a machine learning-based screening tool to identify upper gastrointestinal bleeding (UGIB) patients using multidimensional bowel sound (BS) features. It also explores pathological associations between UGIB-related BSs characteristics and blood biochemical indicators, leveraging feature importance evaluation and SHapley Additive exPlanations analysis to identify interpretable predictors. This study pioneers a noninvasive BS analysis tool for UGIB screening, leveraging multidimensional acoustic feature engineering and machine learning optimization.
Citation	Zhang L, Wang MY, Wei SY, Su C, Hu SY, Ren XY, Liu YP, Liu C, Wan Y. Predicting gastrointestinal bleeding and audio biomarkers based on machine learning analysis of bowel sounds. World J Gastroenterol 2026; In press

Received	2025-10-14 04:52
Peer-Review Started	2025-10-14 04:54
First Decision by Editorial Office Director	2025-12-05 09:29
Return for Revision	2025-12-05 09:29
Revised	2025-12-15 10:34
Publication Fee Transferred	2025-12-20 01:48
Second Decision by Editor	2026-01-30 02:29
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-30 06:40
Articles in Press	2026-01-30 06:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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