Publication Name	World Journal of Gastroenterology
Manuscript ID	115167
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Vasopressin and fluid retention after liver resection: Comparison with the renin-angiotensin-aldosterone system by surgical extent and liver function
Manuscript Source	Unsolicited Manuscript
All Author List	Yuto Aoki, Youich Kawano, Ryo Ga, Kazuhiko Endo, Junji Ueda, Tetsuya Shimizu and Hiroshi Yoshida
Funding Agency and Grant Number	Funding Agency Grant Number Designated Scholarship Donations from Otsuka Pharmaceutical Co., Ltd. to the Authors’ Institution (2018-2019)
Corresponding Author	Youich Kawano, Associate Professor, MD, PhD, Department of Gastroenterological Surgery, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8603, Japan. y-kawano@nms.ac.jp
Key Words	Hepatectomy; Liver resection; Vasopressin; Aldosterone; Fluid management; Water retention; Liver surgery
Core Tip	This study prospectively assessed postoperative changes in arginine vasopressin (AVP) and plasma aldosterone concentration (PAC) after liver resection and found that AVP elevation persisted longer than PAC elevation, particularly after major resections. The duration of elevated AVP closely matched the period of early postoperative fluid retention, highlighting the important role of AVP beyond the renin-angiotensin-aldosterone system. These findings suggest that targeting the V2 signaling pathway may offer strategies for optimizing fluid management and reducing complications in high-risk patients undergoing liver resection. A detailed understanding of postoperative hormonal changes is crucial for future clinical trials and therapeutic decisions.
Citation	Aoki Y, Kawano Y, Ga R, Endo K, Ueda J, Shimizu T, Yoshida H. Vasopressin and fluid retention after liver resection: Comparison with the renin-angiotensin-aldosterone system by surgical extent and liver function. World J Gastroenterol 2026; In press

Received	2025-10-14 03:29
Peer-Review Started	2025-10-14 03:29
First Decision by Editorial Office Director	2025-11-19 10:37
Return for Revision	2025-11-19 10:37
Revised	2025-12-05 15:33
Publication Fee Transferred
Second Decision by Editor	2026-01-16 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-16 08:59
Articles in Press	2026-01-16 08:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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