Publication Name	World Journal of Diabetes
Manuscript ID	115180
Country	China

Category	Otorhinolaryngology
Manuscript Type	Minireviews
Article Title	Metabolic basis of sudden sensorineural hearing loss in diabetes mellitus: From epidemiological association to mechanistic understanding
Manuscript Source	Invited Manuscript
All Author List	Shu-Fen Li, Shu-Yue Yu, Yi-Yuan Liu, Shu-Cai Fu and Yuan-Ping Xiong
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82471183 National Natural Science Foundation of China 82260224 Jiangxi Natural Science Foundation Project 20242BAB25491
Corresponding Author	Yuan-Ping Xiong, MD, PhD, Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, No. 17 Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. xiongyp@ncu.edu.cn
Key Words	Sudden sensorineural hearing loss; Diabetes mellitus; Prediabetes; Mechanisms; Dysglycemia
Core Tip	Growing evidence indicates that diabetes mellitus is not merely a comorbidity but an important contributor to sudden sensorineural hearing loss. Chronic hyperglycemia and early metabolic dysregulation led to cochlear microvascular injury, neuropathy, oxidative stress, and impaired microcirculation, all of which increase susceptibility to hearing loss and hinder recovery. Emerging data suggest that prediabetes may already induce subclinical auditory damage. Elucidating these mechanisms provides a pathophysiological basis for risk stratification, early detection, and more individualized, mechanism-informed treatment strategies in patients with sudden sensorineural hearing loss.
Citation	Metabolic basis of sudden sensorineural hearing loss in diabetes mellitus: From epidemiological association to mechanistic understanding. World J Diabetes 2026; In press

Received	2025-10-10 07:16
Peer-Review Started	2025-10-10 07:23
First Decision by Editorial Office Director	2025-11-11 07:49
Return for Revision	2025-11-11 07:49
Revised	2025-11-22 11:21
Publication Fee Transferred
Second Decision by Editor	2025-12-30 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-07 03:19
Articles in Press	2026-01-07 03:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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