Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115216
Country	China

Category	Oncology
Manuscript Type	Case Report
Article Title	Pleomorphic gastric leiomyosarcoma with retroperitoneal extension and hepatic metastasis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Kun Huang, Wen Wang, Mei-Ling Xu, Yun-Shen He, Jiang-Ying Zhao and Xiao-Feng Hu
Funding Agency and Grant Number	Funding Agency Grant Number Mianyang Municipal Health Commission Scientific Research Fund, Sichuan Province, China No. 202309 Key Laboratory of Development and Utilization of Traditional Chinese Medicine in Mianyang, Sichuan Province, Open Fund 2025 No. 25ZYKF04 2024 Hospital-University Joint Innovation Fund of Chengdu University of Traditional Chinese Medicine No. LH202402010
Corresponding Author	Xiao-Feng Hu, Professor, Department of Nursing, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400000, China. 401366741@qq.com
Key Words	Pleomorphic leiomyosarcoma; Stomach neoplasms; Retroperitoneal involvement; Liver metastasis; Surgical resection; Traditional Chinese medicine; Huaier granules; Case report
Core Tip	Pleomorphic leiomyosarcoma of gastric origin is an exceptionally rare and aggressive tumor, especially when accompanied by retroperitoneal invasion and hepatic metastasis. We report a unique case initially misdiagnosed as retroperitoneal sarcoma, later confirmed intraoperatively to arise from the stomach near the pylorus. Complete curative (R0) resection including distal pancreatectomy and partial hepatectomy achieved favorable short-term outcomes. The patient refused conventional adjuvant therapy and received Huaier granules, a traditional Chinese medicine with potential antitumor effects. This case emphasizes the diagnostic challenges of gastric leiomyosarcoma and suggests that Huaier granules may have a role in postoperative disease control.
Citation	Huang K, Wang W, Xu ML, He YS, Zhao JY, Hu XF. Pleomorphic gastric leiomyosarcoma with retroperitoneal extension and hepatic metastasis: A case report. World J Gastrointest Surg 2026; In press

Received	2025-10-14 06:27
Peer-Review Started	2025-10-14 06:27
First Decision by Editorial Office Director	2025-12-05 09:29
Return for Revision	2025-12-06 01:36
Revised	2025-12-16 15:50
Publication Fee Transferred	2025-12-18 14:27
Second Decision by Editor	2026-01-21 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-21 04:59
Articles in Press	2026-01-21 04:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com