Publication Name	World Journal of Stem Cells
Manuscript ID	115218
Country	China

Category	Orthopedics
Manuscript Type	Basic Study
Article Title	WTAP-mediated N6-methyladenosine modification of circ_PVT1 promotes proliferation and tenogenic differentiation of tendon stem/progenitor cells
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Chen, Xu Hu, Xiao-Tian Jia, Ren-Zhi Gao, Quan-Shan Hou and Shi-Guo Zhou
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Fujian Province 2024J011037
Corresponding Author	Shi-Guo Zhou, MD, Department of Orthopedics, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, No. 134 East Street, Fuzhou 350001, Fujian Province, China. 9201551033@fjmu.edu.cn
Key Words	WTAP; Circular RNA plasmacytoma variant translocation 1; Tenogenic differentiation; Tendon stem/progenitor cells; N6-methyladenosine
Core Tip	Tendon stem/progenitor cells share common characteristics with stem cells, such as proliferation, pluripotency, and self-renewal ability. Under suitable conditions, they can differentiate into tendon cells and play a crucial role in maintaining the stability of tendons and in repair after injury. We found that circular RNA plasmacytoma variant translocation 1 deficiency could inhibit tenogenic differentiation. In addition, WTAP-mediated N6-methyladenosine modification of circular RNA plasmacytoma variant translocation 1 promotes the proliferation and tenogenic differentiation of tendon stem/progenitor cells. These results suggest a promising therapeutic strategy for tendon diseases.
Citation	Chen Y, Hu X, Jia XT, Gao RZ, Hou QS, Zhou SG. WTAP-mediated N6-methyladenosine modification of circ_PVT1 promotes proliferation and tenogenic differentiation of tendon stem/progenitor cells. World J Stem Cells 2026; In press

Received	2025-10-31 08:42
Peer-Review Started	2025-10-31 08:42
First Decision by Editorial Office Director	2025-11-21 06:54
Return for Revision	2025-11-21 06:54
Revised	2025-12-14 06:04
Publication Fee Transferred	2025-12-19 10:10
Second Decision by Editor	2026-02-24 02:57
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-24 08:13
Articles in Press	2026-02-24 08:13
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Typeset the Manuscript

ISSN	1948-0210 (online)
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