Publication Name	World Journal of Methodology
Manuscript ID	115219
Country	Rwanda

Category	Medicine, General & Internal
Manuscript Type	Clinical Trials Study
Article Title	Cortical arousal and autonomic regulation: The role of cold vs tepid caffeinated beverages during prolonged orthostasis
Manuscript Source	Invited Manuscript
All Author List	Mayowa J Adeniyi and Ayoola Awosika
Funding Agency and Grant Number
Corresponding Author	Mayowa J Adeniyi, Assistant Professor, PhD, Department of Physiology, University of Rwanda, College of Medicine and Health Sciences, KG 11 Ave, Kigali 01000, Rwanda. 7jimade@gmail.com
Key Words	Orthostasis; Orthostatic syncope; Cold caffeinated beverage; Tepid caffeinated beverage; Alpha/beta ratio; Alpha waves; Beta waves
Core Tip	Electroencephalogram biomarkers highlight temperature-dependent differences in neurophysiologic adaptation and resilience to orthostatic stress. These findings underscore the potential of beverage-based interventions as simple, non-pharmacologic strategies to mitigate presyncope and fatigue. A significant finding from this study was the insignificant difference in alpha/beta ratio between orthostatic individuals administered tepid caffeinated beverage and orthostatic individuals who were given cold caffeinated beverage despite the fact that orthostatic individual who ingested tepid caffeinated beverage exhibited higher beta wave frequency when compared to orthostatic individuals administered cold caffeinated beverage.
Citation	Adeniyi MJ, Awosika A. Cortical arousal and autonomic regulation: The role of cold vs tepid caffeinated beverages during prolonged orthostasis. World J Methodol 2026; In press

Received	2025-10-11 00:37
Peer-Review Started	2025-10-11 00:37
First Decision by Editorial Office Director	2025-11-11 08:47
Return for Revision	2025-11-11 08:47
Revised	2025-11-12 23:07
Publication Fee Transferred
Second Decision by Editor	2026-01-06 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-07 01:28
Articles in Press	2026-01-07 01:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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