Publication Name	World Journal of Gastroenterology
Manuscript ID	115226
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	High-frequency irreversible electroporation synergizes with PD-1/PD-L1 inhibitor BMS-1 and TLR7/8 agonist R848 to potentiate liver cancer antitumor immunity
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Ming Huang, Xiao-Bo Zhang, Jing Li, Guo-Hui Zhang, Xiao Zhang, Ying-Tian Wei, Hui Sun, Li Ma, Zhen-Jun Wang, Di-Xiao Yao, Hong-Jian Shi, Ti Wang and Yue-Yong Xiao
Funding Agency and Grant Number
Corresponding Author	Yue-Yong Xiao, Department of Radiology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. fszdk_301@163.com
Key Words	Liver cancer; High-frequency irreversible electroporation; Programmed death-1/programmed death-ligand 1 inhibitor; Toll-like receptor 7/8 agonist; Antitumor immunity
Core Tip	High-frequency irreversible electroporation potently triggers immunogenic cell death within tumors. In combination with BMS-1 and R848, this multimodal strategy not only curbs tumor progression but also dynamically reprograms the immunosuppressive tumor microenvironment. Specifically, it augments the infiltration of CD3+ CD4+ and CD3+ CD8+ T cells, CD11c+ CD80+ CD86+ dendritic cells, and F4/80+ CD11b+ CD86+ M1 macrophages, while depleting immunosuppressive subsets such as CD4+ CD25+ FOXP3+ regulatory T cells and F4/80+ CD11b+ CD206+ M2 macrophages. Consequently, the regimen induces a pronounced abscopal effect and fosters robust, systemic antitumor immunity, underscoring its translational potential as an innovative combination immunotherapy.
Citation	Huang SM, Zhang XB, Li J, Zhang GH, Zhang X, Wei YT, Sun H, Ma L, Wang ZJ, Yao DX, Shi HJ, Wang T, Xiao YY. High-frequency irreversible electroporation synergizes with PD-1/PD-L1 inhibitor BMS-1 and TLR7/8 agonist R848 to potentiate liver cancer antitumor immunity. World J Gastroenterol 2026; In press

Received	2025-10-14 14:40
Peer-Review Started	2025-10-14 14:41
First Decision by Editorial Office Director	2025-12-02 08:16
Return for Revision	2025-12-02 08:16
Revised	2025-12-08 13:27
Publication Fee Transferred	2025-12-18 13:31
Second Decision by Editor	2026-02-10 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-10 08:11
Articles in Press	2026-02-10 08:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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