Publication Name	World Journal of Gastroenterology
Manuscript ID	115232
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Endocrine-liver bidirectional regulation: From mechanistic research to multidisciplinary clinical practice
Manuscript Source	Unsolicited Manuscript
All Author List	Kai-Rui Wan, Cheng Qian and Li-Mei Liu
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Sciences Foundation of China 82273071
Corresponding Author	Li-Mei Liu, Associate Professor, PhD, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, No. 131 Yubei Road, Shapingba District, Chongqing 400030, China. limeilliu@126.com
Key Words	Endocrine system; Liver function; Multidisciplinary team; Metabolic liver disease; Hormonal imbalance
Core Tip	The endocrine system and liver form a dynamic bidirectional network via hormone synthesis/metabolism and signaling regulation. Hormones (e.g., thyroid hormones, insulin) maintain hepatic glucose/lipid homeostasis and bile acid metabolism; conversely, chronic liver diseases disrupt endocrine balance through impaired hormone clearance, hypothalamic–pituitary axis dysfunction, and systemic inflammation, forming a “liver disease–endocrine disorder” vicious cycle. Key research gaps include insufficient exploration of the gut microbiota-endocrine-liver axis, lack of special population data, and delayed integration of emerging therapies. Future efforts should focus on molecular mechanism refinement, special population studies, and multidisciplinary team practice to achieve precise management of endocrine-related liver diseases.
Citation	Wan KR, Qian C, Liu LM. Endocrine-liver bidirectional regulation: From mechanistic research to multidisciplinary clinical practice. World J Gastroenterol 2025; In press

Received	2025-10-14 05:48
Peer-Review Started	2025-10-14 05:51
First Decision by Editorial Office Director	2025-11-14 09:20
Return for Revision	2025-11-14 09:20
Revised	2025-11-17 14:58
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 07:56
Articles in Press	2025-12-15 07:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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