Publication Name	World Journal of Gastroenterology
Manuscript ID	115234
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Study on the mechanism of hepatitis C virus-mediated development and progression of liver cirrhosis and hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Kai-Rui Wan, Cheng Qian and Li-Mei Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Sciences Foundation of China 82273071
Corresponding Author	Li-Mei Liu, Associate Professor, MD, PhD, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, No. 131 Yubei Road, Shapingba District, Chongqing 400030, China. limeilliu@126.com
Key Words	Hepatitis C virus; Liver cirrhosis; Hepatocellular carcinoma; Estrogen receptor; Tumor necrosis factor-alpha; Sex difference
Core Tip	The study by Groover et al is the first to systematically analyze the expression differences and sex-specific correlations of estrogen receptor subtypes and tumor necrosis factor-alpha in the livers of healthy individuals and patients with hepatitis C virus (HCV)-related liver diseases. The study confirms that the expression changes of estrogen receptor β and tumor necrosis factor-alpha are important factors involved in HCV-mediated progression of liver cirrhosis and hepatocellular carcinoma, and sex-specific molecular regulation may be a key mechanism underlying the prognostic differences of HCV-related diseases.
Citation	Wan KR, Qian C, Liu LM. Study on the mechanism of hepatitis C virus-mediated development and progression of liver cirrhosis and hepatocellular carcinoma. World J Gastroenterol 2025; In press

Received	2025-10-14 05:44
Peer-Review Started	2025-10-14 05:44
First Decision by Editorial Office Director	2025-11-06 09:36
Return for Revision	2025-11-06 09:36
Revised	2025-11-10 14:56
Publication Fee Transferred
Second Decision by Editor	2025-12-24 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-24 10:50
Articles in Press	2025-12-24 10:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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