Publication Name	World Journal of Gastroenterology
Manuscript ID	115244
Country	China

Category	Pathology
Manuscript Type	Letter to the Editor
Article Title	Unmasking the high-risk phenotype in autoimmune gastritis: A pathologist’s roadmap for the clinician
Manuscript Source	Invited Manuscript
All Author List	Cheng-Long Wang, Min Zeng and Yan Luo
Funding Agency and Grant Number	Funding Agency Grant Number Chongqing Health Commission and Science and Technology Bureau No. 2023MSXM060
Corresponding Author	Yan Luo, MD, Department of Stomatology, The People’s Hospital of Dadukou District, No. 102 Cuibai Road, Dadukou District, Chongqing 400084, China. luokate88@gmail.com
Key Words	Pathology; Autoimmune gastritis; Gastric neuroendocrine tumors; Precursor lesions; Dysplasia
Core Tip	Clinical risk models identify patients with autoimmune gastritis who may develop neuroendocrine tumors, but pathology guides what to do next. We advocate for a “prognostic biopsy protocol” where pathologists report the specific stage of microscopic pre-cancerous lesions. Finding high-risk changes, especially dysplasia, serves as a clear trigger to intensify surveillance. This approach allows clinicians to manage risk proactively based on a patient’s real-time biology, rather than waiting for a visible tumor to develop.
Citation	Wang CL, Zeng M, Luo Y. Unmasking the high-risk phenotype in autoimmune gastritis: A pathologist’s roadmap for the clinician. World J Gastroenterol 2025; In press

Received	2025-10-15 02:17
Peer-Review Started	2025-10-15 02:17
To Make the First Decision
Return for Revision	2025-10-21 09:36
Revised	2025-10-28 13:01
Second Decision	2025-11-12 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-12 11:03
Articles in Press	2025-11-12 11:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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