Publication Name	World Journal of Clinical Oncology
Manuscript ID	115245
Country	Italy

Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Palpable vs non-palpable breast cancers in screened populations: Clinicopathological features and prognostic implications
Manuscript Source	Invited Manuscript
All Author List	Luca Improta, Gianluca Stanzani, Valeria Vitale, Marco Yusef, Simone Tinghino and Augusto Lombardi
Funding Agency and Grant Number
Corresponding Author	Luca Improta, MD, PhD, Breast Unit, Azienda Ospedaliero-Universitaria Sant’Andrea, Via Di Grottarossa 1035/1039, Rome 00189, Lazio, Italy. luca.dr.improta@gmail.com
Key Words	Breast cancer; Palpable tumor; Tumor aggressiveness; Mammographic screening; Clinicopathological features; Survival outcomes; Ki-67 index; Tumor biology; Prognostic factors; Screening-detected cancer
Core Tip	Despite widespread mammographic screening, many breast cancers still present as palpable masses. This large cohort study (n = 2110) reveals that palpable tumors exhibit aggressive biology-larger size (17.5 mm vs 11.0 mm, P < 0.001), higher grade (G3) (33% vs 16%), elevated Ki-67 (24.7% vs 15.1%), and more frequent luminal B/TN subtypes (P < 0.001). While 10-year survival remained excellent (> 90%) for both groups, palpability served as a clinical marker of rapid tumor growth, underscoring its utility in risk stratification. Findings highlight that even in screened populations, palpable presentation may signal biologically aggressive disease warranting tailored management.
Citation	Improta L, Stanzani G, Vitale V, Yusef M, Tinghino S, Lombardi A. Palpable vs non-palpable breast cancers in screened populations: Clinicopathological features and prognostic implications. World J Clin Oncol 2025; In press

Received	2025-10-15 02:56
Peer-Review Started	2025-10-15 02:56
First Decision by Editorial Office Director	2025-10-30 08:52
Return for Revision	2025-10-30 08:52
Revised	2025-11-11 09:47
Publication Fee Transferred
Second Decision by Editor	2025-12-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 08:41
Articles in Press	2025-12-25 08:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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