Publication Name	World Journal of Nephrology
Manuscript ID	115252
Country	Mexico

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Hyponatremia: Evolving diagnostics and emerging therapeutics in clinical practice
Manuscript Source	Invited Manuscript
All Author List	Froylan David Martínez-Sánchez, Luis Enrique Gutierrez-Rosas, Luis Hernan Barranco-Hernandez, Gibran Gonzalez-Alvarez, Luis A Bastida-Castro, Andrea Rocha-Haro, German Barrientos-Cabrera, Carlos Fernando Martínez-Cabrera, Joana Balderas-Juarez, Mauricio A Salinas-Ramirez and Jose L Hernandez-Castillo
Funding Agency and Grant Number
Corresponding Author	Froylan David Martínez-Sánchez, MD, Professor, Department of Internal Medicine, Hospital General Dr. Manuel Gea Gonzalez, Calz. de Tlalpan 4800, Belisario Domínguez Secc 16, Tlalpan 14080, Ciudad de México, Mexico. froylan.martinez@comunidad.unam.mx
Key Words	Hyponatremia; Fluid restriction; Furst equation; Point-of-care ultrasound; Hypertonic saline; Urea; Tolvaptan
Core Tip	Hyponatremia, defined as a low concentration of sodium in the blood, is the most frequent electrolyte disorder in clinical practice. Its causes are diverse and often overlap, from hormonal imbalances to medication effects or underlying heart, liver, and kidney conditions. Effective and safe correction depends on accurately identifying whether the body has too much or too little water, rather than simply restricting fluids. Bedside ultrasound (point-of-care ultrasonography) and simple laboratory tools such as the Furst equation allow clinicians to assess fluid status objectively, predict response to fluid restriction, and guide personalized treatment strategies that reduce complications and improve patient outcomes.
Citation	Martínez-Sánchez FD, Gutierrez-Rosas LE, Barranco-Hernandez LH, Gonzalez-Alvarez G, Bastida-Castro LA, Rocha-Haro A, Barrientos-Cabrera G, Martínez-Cabrera CF, Balderas-Juarez J, Salinas-Ramírez MA, Hernández-Castillo JL. Hyponatremia: Evolving diagnostics and emerging therapeutics in clinical practice. World J Nephrol 2026; In press

Received	2025-10-15 02:58
Peer-Review Started	2025-10-15 02:58
First Decision by Editorial Office Director	2025-11-05 08:56
Return for Revision	2025-11-05 08:56
Revised	2025-11-19 23:13
Publication Fee Transferred
Second Decision by Editor	2026-01-16 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-16 07:48
Articles in Press	2026-01-16 07:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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