Publication Name	World Journal of Gastroenterology
Manuscript ID	115264
Country	China

Category	Infectious Diseases
Manuscript Type	Observational Study
Article Title	Characteristics of gut microbiota and metabolites in patients with ulcerative colitis with fatigue
Manuscript Source	Invited Manuscript
All Author List	Zi-Xuan Liu, Xiao-Yan Liu, Wei-Wei Tan, Wei-Bing Zhang, Ya-Li Zhang, Lie Zheng and Yan-Cheng Dai
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81873253 National Natural Science Foundation of China 82574996 the Shanghai Natural Science Foundation 22ZR1458800 the Scientific Research Project Plan of Shanghai Municipal Health Commission 202240385 Hongkou District Health Committee HKZK2020A01 Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project TZKN-CXRC-16 Project of Shaanxi Administration of Traditional Chinese Medicine SZY-KJCYC-2025-JC-010 Shaanxi Province Key Research and Development Plan Project-Social Development Field 2025SF-YBXM-498
Corresponding Author	Yan-Cheng Dai, Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital Shanghai University of Traditional Chinese Medicine, No. 230 Baoding Road, Hongkou District, Shanghai 200082, China. daiyancheng2005@126.com
Key Words	Ulcerative colitis; Fatigue; Gut Microbiota; Metabolites; Thromboxane; Anaerococcus
Core Tip	The relationship between disease severity and gut microbes and metabolites in patients with ulcerative colitis (UC) with fatigue remains unclear. To investigate this relationship, we collected fresh stool samples from patients with UC with/without fatigue and healthy individuals with/without fatigue for 16S rRNA sequencing and untargeted metabolomic analysis. Results revealed the gut microbial and metabolomic characteristics of patients with UC with fatigue (HUCF). Patients with HUCF exhibited a distinct gut microbial structure and metabolomic profile. Metabolomic analysis revealed differential expression of metabolites such as linoleoyl ethanolamide, arachidonoyl ethanolamide, glycocholic acid, and thromboxane. Patients with HUCF showed a high relative abundance of Anaerococcus, a beneficial genus.
Citation	Liu ZX, Liu XY, Tan WW, Zhang WB, Zhang YL, Zheng L, Dai YC. Characteristics of gut microbiota and metabolites in patients with ulcerative colitis with fatigue. World J Gastroenterol 2025; In press

Received	2025-10-15 02:52
Peer-Review Started	2025-10-15 02:52
First Decision by Editorial Office Director	2025-11-10 08:01
Return for Revision	2025-11-10 08:01
Revised	2025-11-19 02:30
Publication Fee Transferred
Second Decision by Editor	2025-12-09 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-10 01:11
Articles in Press	2025-12-10 01:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com