Publication Name	World Journal of Methodology
Manuscript ID	115265
Country	Italy

Category	Ophthalmology
Manuscript Type	Opinion Review
Article Title	Artificial intelligence in ophthalmology: From diagnostic accuracy to clinical application
Manuscript Source	Invited Manuscript
All Author List	Marco Zeppieri, Matteo Capobianco, Federico Visalli, Marieme Khouyyi, Mutali Musa, Alessandro Avitabile, Inferrera Leandro, Rosa Giglio, Daniele Tognetto, Caterina Gagliano, Fabiana D’Esposito and Francesco Cappellani
Funding Agency and Grant Number
Corresponding Author	Caterina Gagliano, MD, PhD, Department of Medicine and Surgery, Kore University of Enna, Viale delle Olimpiadi 1, Enna 94100, Italy. caterina.gagliano@unikore.it
Key Words	Ophthalmology; Artificial intelligence; Image classification; Diagnostic precision; Clinical validation
Core Tip	Artificial intelligence offers potential for enhancing ocular diagnoses; nevertheless, greater algorithmic accuracy at the image level rarely translates to improved patient outcomes. Obstacles, including data bias, domain shift, and label noise, coupled with a scarcity of prospective research and a lack of cost-effectiveness or equity evaluations, impede translation. Enhancing external validation, establishing predetermined thresholds, and incorporating human-factors engineering into healthcare workflows are imperative. Bridging this gap could convert algorithmic accuracy into significant diagnostic precision for glaucoma, diabetic retinopathy, and macular conditions.
Citation	Zeppieri M, Capobianco M, Visalli F, Khouyyi M, Musa M, Avitabile A, Leandro I, Giglio R, Tognetto D, Gagliano C, D’Esposito F, Cappellani F. Artificial intelligence in ophthalmology: From diagnostic accuracy to clinical application. World J Methodol 2026; In press

Received	2025-10-15 02:21
Peer-Review Started	2025-10-15 02:21
First Decision by Editorial Office Director	2025-11-10 07:11
Return for Revision	2025-11-10 07:11
Revised	2025-11-12 06:59
Publication Fee Transferred
Second Decision by Editor	2026-01-21 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-21 08:41
Articles in Press	2026-01-21 08:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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