Publication Name	World Journal of Gastroenterology
Manuscript ID	115291
Country	China

Category	Pharmacology & Pharmacy
Manuscript Type	Observational Study
Article Title	Cost-effectiveness of different strategies with biologics for the treatment of moderate to severe Crohn’s disease in China
Manuscript Source	Unsolicited Manuscript
All Author List	Yao Wu, Li-Bo Tao, Chang Liu, Fang-Xu Wang, Yi Yan and Shuang Sun
Funding Agency and Grant Number
Corresponding Author	Li-Bo Tao, PhD, Senior Researcher, Center for Health Policy and Technology Evaluation, Peking University Health Science Center, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China. taolibo@hsc.pku.edu.cn
Key Words	Crohn’s disease; Biologics; Treatment sequence; Cost-effectiveness; China; Outcomes
Core Tip	Using a Markov model, this study evaluated the cost-effectiveness of 17 sequential biologic strategies for moderate-to-severe Crohn’s Disease in China. Under a willingness-to-pay threshold of one times the 2024 GDP per capita, the findings suggest that while additional lines of biologic therapy improve health outcomes, they concurrently increase costs. The sequence initiating with adalimumab and followed by ustekinumab emerged as the most cost-effective option, yielding the highest net monetary benefit and a favorable incremental cost-effectiveness ratio for both biologic-naïve and biologic-exposed patients.
Citation	Wu Y, Tao LB, Liu C, Wang FX, Yan Y, Sun S. Cost-effectiveness of different strategies with biologics for the treatment of moderate to severe Crohn’s disease in China. World J Gastroenterol 2026; In press

Received	2025-10-15 08:21
Peer-Review Started	2025-10-15 08:22
First Decision by Editorial Office Director	2025-12-09 09:39
Return for Revision	2025-12-09 09:39
Revised	2025-12-23 07:08
Publication Fee Transferred	2025-12-24 06:13
Second Decision by Editor	2026-02-03 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-03 06:28
Articles in Press	2026-02-03 06:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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