Publication Name	World Journal of Gastroenterology
Manuscript ID	115299
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Berberine alleviates experimental colitis by enhancing gut-microbiota-dependent intestinal barrier function and suppressing gasdermin D activation
Manuscript Source	Unsolicited Manuscript
All Author List	Ping Yang, Ran Wang, Yu-Ping Zhou, Jin-Feng Wen and Dong-Xue Yang
Funding Agency and Grant Number	Funding Agency Grant Number Zhejiang Provincial Natural Science Foundation of China LQ22H030004 Zhejiang Provincial Natural Science Foundation of China LBY23H200006 Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2024KY324 Zhejiang Provincial Traditional Chinese Medicine Science and Technology Project 2025ZL115 Ningbo “Kechuang Yongjiang 2035” Major Research and Development Program 2025Z150 Ningbo Top Medical and Health Research Program 2023020612
Corresponding Author	Dong-Xue Yang, Assistant Professor, Ningbo Key Laboratory of Translational Medicine Research on Gastroenterology and Hepatology, The First Affiliated Hospital of Ningbo University, No. 247 Renmin Road, Jiangbei District, Ningbo 315020, Zhejiang Province, China. fyyangdongxue@nbu.edu.cn
Key Words	Ulcerative colitis; Berberine; Gasdermin D; Intestinal inflammation; Intestinal microbiota
Core Tip	Berberine alleviates dextran sulfate sodium-induced murine ulcerative colitis through a mechanism that involves gut microbiota-dependent enhancement of intestinal barrier function and suppression of gasdermin D activation. Fecal microbiota transplantation and cohousing studies underscore the pivotal role of the microbiota, while gasdermin D inhibition diminishes the therapeutic efficacy of berberine, suggesting a novel therapeutic target for colitis.
Citation	Yang P, Wang R, Zhou YP, Wen JF, Yang DX. Berberine alleviates experimental colitis by enhancing gut-microbiota-dependent intestinal barrier function and suppressing gasdermin D activation. World J Gastroenterol 2026; In press

Received	2025-10-21 02:19
Peer-Review Started	2025-10-21 02:19
First Decision by Editorial Office Director	2025-11-25 09:26
Return for Revision	2025-11-25 09:26
Revised	2025-12-08 08:44
Publication Fee Transferred	2025-12-09 06:35
Second Decision by Editor	2026-01-15 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-15 04:11
Articles in Press	2026-01-15 04:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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