Publication Name	World Journal of Psychiatry
Manuscript ID	115300
Country	China

Category	Psychiatry
Manuscript Type	Review
Article Title	Progress on the neurotrophic effects of antidepressant drugs
Manuscript Source	Invited Manuscript
All Author List	Pan Jing, Xi-Cheng Liu, Xiao-Peng Yin, Ye Fu, Qing Tian and Xiao-Bin Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Ningbo Top Medical and Health Research Program 2022030410 Zhejiang Medical and Health Science and Technology Project 2023KY1126 Suzhou Clinical Medical Center for Mood Disorders Szlcyxzx202109 Suzhou Key Laboratory SZS2024016 Multicenter Clinical Research on Major Diseases in Suzhou DZXYJ202413
Corresponding Author	Xiao-Bin Zhang, Department of Psychiatry, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow University, No. 11 Guangqian Road, Xiangcheng District, Suzhou 215137, Jiangsu Province, China. zhangxiaobim@163.com
Key Words	Major depressive disorder; Neurotrophic factors; Synaptic plasticity; Neurogenesis; Antidepressant drugs
Core Tip	Major depressive disorder (MDD) is a complex disorder involving multiple neurotransmitters and brain regions. In patients with MDD, alterations may occur in the stability and functionality of these neural networks, extending beyond mere chemical imbalances. Antidepressants have neurotrophic effects that can enhance synaptic connections and stimulate the growth of new neurons, thus helping restore the function of neural networks. Synaptic and neurogenic enhancements induced by antidepressants require time to manifest and develop. These advances may yield more effective and safer antidepressants and improve the use of existing medications for patients with MDD.
Citation	Jing P, Liu XC, Yin XP, Fu Y, Tian Q, Zhang XB. Progress on the neurotrophic effects of antidepressant drugs. World J Psychiatry 2025; In press

Received	2025-10-15 08:34
Peer-Review Started	2025-10-15 08:34
First Decision by Editorial Office Director	2025-11-05 06:31
Return for Revision	2025-11-05 06:31
Revised	2025-11-17 03:20
Publication Fee Transferred
Second Decision by Editor	2025-12-18 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-18 09:17
Articles in Press	2025-12-18 09:17
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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