Publication Name	World Journal of Gastroenterology
Manuscript ID	115332
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	PRMT5 imposed a dual repression on DDIT3 transcription to promote the malignancy of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Hao Jiang, Jin-Hua Yan, Wen-Jing Tang, Bin Shen, Shuai Mo, Yang Wang, De-Hua Hu, Zhi-Xiong Dong and Shu-Bing Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82573818 Natural Science Foundation of Hunan Province of China No. 2025JJ50542 Key Laboratory of School of Laboratory Medicine and Life Sciences, Wenzhou Medical University No. JS2023005
Corresponding Author	Shu-Bing Zhang, Manager, Professor, Researcher, Department of Cell Biology, School of Life Sciences, Central South University, No. 172 Tongzipo, Yuelu District, Changsha 410013, Hunan Province, China. shubingzhang@csu.edu.cn
Key Words	Hepatocellular carcinoma; PRMT5; HLCL-61; Apoptosis; Symmetrical dimethylation
Core Tip	High PRMT5 expression was correlated with a worse prognosis of hepatocellular carcinoma (HCC), and inhibition of PRMT5 expression significantly decreased the viability of HCC cells by inducing apoptosis. Mechanistically, PRMT5 dually suppressed the promoter activity of the apoptosis-inducing factor DDIT3 by increasing H4R3me2 modification and recruiting STAT3 to its promoter. The PRMT5 inhibitor HLCL-61 exerted excellent inhibitory efficacy on HCC cells and tissue derived tumors. In general, our study demonstrated that PRMT5 served as an adaptor for STAT3, displaying a dual inhibitory role on DDIT3 transcription to promote apoptosis resistance, and provided that its inhibitor HLCL-61 was an alternative therapeutic approach of HCC.
Citation	Jiang H, Yan JH, Tang WJ, Shen B, Mo S, Wang Y, Hu DH, Dong ZX, Zhang SB. PRMT5 imposed a dual repression on DDIT3 transcription to promote the malignancy of hepatocellular carcinoma. World J Gastroenterol 2026; In press

Received	2025-10-17 11:31
Peer-Review Started	2025-10-17 11:31
First Decision by Editorial Office Director	2025-11-19 10:41
Return for Revision	2025-11-19 10:41
Revised	2025-12-28 13:06
Publication Fee Transferred
Second Decision by Editor	2026-02-14 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-14 07:48
Articles in Press	2026-02-14 07:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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