Publication Name	World Journal of Diabetes
Manuscript ID	115342
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Editorial
Article Title	RRM2 and the ferroptosis-oxidative stress axis in diabetic kidney disease: A new path toward therapeutic intervention
Manuscript Source	Invited Manuscript
All Author List	Tong-Jian Zhao and Nian-Zhe Sun
Funding Agency and Grant Number
Corresponding Author	Nian-Zhe Sun, MD, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Kaifu District, Changsha, Hunan, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Key Words	Diabetic kidney disease; Ferroptosis; Oxidative stress; RRM2; PI3K/Akt/Nrf2 signaling; Tubular injury
Core Tip	RRM2 protects against ferroptosis-mediated renal tubular damage by activating the PI3K/Akt/Nrf2 signaling pathway. This discovery deepens our understanding of diabetic kidney disease (DKD) pathogenesis, highlights RRM2 as both a potential biomarker and a therapeutic target. Therefore, strategies for preventing and treating DKD should consider modulating ferroptosis.
Citation	Zhao TJ, Sun NZ. RRM2 and the ferroptosis-oxidative stress axis in diabetic kidney disease: A new path toward therapeutic intervention. World J Diabetes 2025; In press

Received	2025-10-15 02:41
Peer-Review Started	2025-10-15 03:40
First Decision by Editorial Office Director	2025-12-05 09:15
Return for Revision	2025-12-05 09:15
Revised	2025-12-11 07:36
Publication Fee Transferred
Second Decision by Editor	2025-12-29 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-29 05:37
Articles in Press	2025-12-29 05:37
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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