Publication Name	World Journal of Psychiatry
Manuscript ID	115373
Country	Brazil

Category	Neurosciences
Manuscript Type	Observational Study
Article Title	Multidimensional cognitive impairment in hepatosplenic schistosomiasis: A cross-sectional study
Manuscript Source	Invited Manuscript
All Author List	Iris Campos Lucas, Norma Arteiro Filgueira, Ana Lucia Domingues, Edmundo Pessoa Lopes, Ianca Karine Prudencio Albuquerque and Breno José Alencar Pires Barbosa
Funding Agency and Grant Number
Corresponding Author	Iris Campos Lucas, PhD, Professor, Programa de Pós-Graduação em Medicina Tropical, Centro de Ciências Médicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, No. 1235 Cidade Universitária, Recife 50670-901, Pernambuco, Brazil. iriscamposlucas@gmail.com
Key Words	Cognitive impairment; Schistosomiasis mansoni; Portal hypertension; Neuropsychological tests; Executive function; Hepatic encephalopathy; Portosystemic shunts; Psychometric; Cross-sectional studies
Core Tip	Cognitive impairment in hepatosplenic schistosomiasis goes well beyond minimal hepatic encephalopathy, affecting areas such as visuospatial abilities, working memory, and inhibitory control. Our study, using a brief, culturally adapted assessment battery, found over two-thirds of patients impaired in these domains, often independent of portosystemic shunt presence. These findings call for a paradigm shift from solely minimal hepatic encephalopathy-focused screening to comprehensive, multidimensional cognitive assessment in hepatosplenic schistosomiasis, enabling earlier detection and a more holistic approach to management in endemic, low-resource settings.
Citation	Lucas IC, Filgueira NA, Domingues AL, Lopes EP, Albuquerque IKP, Barbosa BJAP. Multidimensional cognitive impairment in hepatosplenic schistosomiasis: A cross-sectional study. World J Psychiatry 2025; In press

Received	2025-10-16 14:27
Peer-Review Started	2025-10-16 14:28
First Decision by Editorial Office Director	2025-11-06 08:43
Return for Revision	2025-11-06 08:43
Revised	2025-11-14 19:16
Publication Fee Transferred
Second Decision by Editor	2025-12-25 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 03:33
Articles in Press	2025-12-25 03:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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