Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115383
Country	China

Category	Surgery
Manuscript Type	Clinical Trials Study
Article Title	Impact of indomethacin combined with pancreatic duct stent placement on high-risk populations of pancreatitis after endoscopic retrograde cholangiopancreatography
Manuscript Source	Unsolicited Manuscript
All Author List	Kai Xu, Dong-Hai Zhou, Jing-Shan Liu and Jian Feng
Funding Agency and Grant Number
Corresponding Author	Kai Xu, MD, PhD, Department of General Surgery, Peking University Shougang Hospital, No. 9 Jinyuangzhuang Road, Beijing 100041, China. xking55555@163.com
Key Words	Post-operative pancreatitis; Endoscopic retrograde cholangiopancreatography; Pancreatic duct stent; Indomethacin
Core Tip	This study demonstrates that combining indomethacin suppositories with pancreatic duct stent placement significantly reduces postoperative inflammatory markers (interleukin-6, interleukin-10, C-reactive protein) and improves immune function (higher CD4+/CD8+ ratio) in high-risk post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) patients. The dual intervention also shortens pain relief time and hospital stays compared to monotherapy, offering a synergistic strategy to mitigate PEP-related complications. Key findings highlight its superiority in modulating inflammation and enhancing recovery without increasing severe PEP incidence.
Citation	Xu K, Zhou DH, Liu JS, Feng J. Impact of indomethacin combined with pancreatic duct stent placement on high-risk populations of pancreatitis after endoscopic retrograde cholangiopancreatography. World J Gastrointest Surg 2026; In press

Received	2025-10-24 07:39
Peer-Review Started	2025-10-24 07:39
First Decision by Editorial Office Director	2025-11-18 05:18
Return for Revision	2025-11-18 05:18
Revised	2025-11-28 09:56
Publication Fee Transferred	2025-12-02 00:56
Second Decision by Editor	2026-01-12 02:45
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 06:27
Articles in Press	2026-01-12 06:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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