Publication Name	World Journal of Critical Care Medicine
Manuscript ID	115389
Country	India

Category	Critical Care Medicine
Manuscript Type	Randomized Controlled Trial
Article Title	Impact of magnesium on the clearance of lactate in critically sick patients with sepsis: Randomized clinical trial
Manuscript Source	Invited Manuscript
All Author List	Chakkaravarthe Anbarasan, Ankur Sharma, Nikhil Kothari, Tanvi M Meshram, Kamlesh Kumari, Shilpa Goyal and Pradeep K Bhatia
Funding Agency and Grant Number
Corresponding Author	Ankur Sharma, Additional Professor, Consultant, MD, Department of Trauma and Emergency (Anaesthesiology and Critical Care), All India Institute of Medical Sciences, Basni Industrial Area, Jodhpur 342008, Rājasthān, India. ankuranaesthesia@gmail.com
Key Words	Lactate; Magnesium; Sepsis; Intensive care unit, Lactate clearance
Core Tip	Early lactate clearance is a key therapeutic target and prognostic marker in sepsis. In this randomized clinical trial, magnesium supplementation significantly accelerated lactate clearance in critically ill patients with sepsis and was associated with reduced vasopressor requirements, shorter intensive care unit stay, and decreased overall hospital stay. Although the magnesium group demonstrated a numerically lower 28-day mortality, this difference did not reach statistical significance.
Citation	Anbarasan C, Sharma A, Kothari N, Meshram TM, Kumari K, Goyal S, Bhatia PK. Impact of magnesium on the clearance of lactate in critically sick patients with sepsis: Randomized clinical trial. World J Crit Care Med 2026; In press

Received	2025-10-17 06:59
Peer-Review Started	2025-10-17 07:00
First Decision by Editorial Office Director	2025-11-30 01:33
Return for Revision	2025-11-30 01:33
Revised	2025-12-13 11:16
Publication Fee Transferred
Second Decision by Editor	2026-02-14 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-14 07:07
Articles in Press	2026-02-14 07:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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