Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	115401
Country	India

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Advancing precision medicine in human epidermal growth factor receptor 2 negative gastric cancer: Insights from a novel nomogram for immunochemotherapy prognosis
Manuscript Source	Invited Manuscript
All Author List	Abinash Nayak, Gunanidhi Sahoo and Sudhansu Sekhar Nishank
Funding Agency and Grant Number
Corresponding Author	Abinash Nayak, Academic Fellow, Assistant Professor, Lecturer, Research Fellow, Researcher, Post-graduate Department of Zoology, Utkal University, Vani Vihar, Bhubaneshwar 751004, Odisha, India. abinashnayakzoology@gmail.com
Key Words	Gastric cancer; Human epidermal growth factor receptor 2; Immunochemotherapy; Nomogram; Prognostic model; Biomarkers; Precision oncology
Core Tip	The nomogram by Yao et al represents a comprehensive tool for prognosticating outcomes in advanced human epidermal growth factor receptor 2-negative gastric cancer patients on immunochemotherapy. By incorporating immune, clinicopathological, and inflammatory markers, it achieves high discriminative power. Recent advancements in circulatory tumor DNA, artificial intelligence-radiomics, and combination therapies like claudin 18.2-targeting complement this model, highlighting the need for prospective validation to enhance clinical utility.
Citation	Nayak A, Sahoo G, Nishank SS. Advancing precision medicine in human epidermal growth factor receptor 2 negative gastric cancer: Insights from a novel nomogram for immunochemotherapy prognosis. World J Gastrointest Oncol 2025; In press

Received	2025-10-17 12:49
Peer-Review Started	2025-10-17 12:55
To Make the First Decision
Return for Revision	2025-10-22 06:43
Revised	2025-10-24 15:29
Second Decision	2025-11-27 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-27 08:24
Articles in Press	2025-11-27 08:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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