| Category |
Hematology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Anatomical laterality of primary intestinal diffuse large B-cell lymphoma independently stratifies survival: New prognostic nomogram incorporating tumor location
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui-Xin Zeng, Cai-Qin Wang, Hang Yang, Peng Sun, Pan-Pan Liu, Lin-Chuan Wei, Ting-Ting Chen, Zhao Wang, He Huang, Zhi-Ming Li, Xiao-Peng Tian and Yu Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82104273 |
| National Natural Science Foundation of China |
No. 82422010 |
| National Natural Science Foundation of China |
No. 82370190 |
| National Natural Science Foundation of China |
No. 82204414 |
| Guangdong Basic and Applied Basic Research Foundation |
No. 2024B1515020026 |
| Hunan Provincial Natural Science Foundation of China |
No. 2025JJ60485 |
| Innovative Tumor Supportive Care Research Project |
No. cphcf-2023-157 |
|
| Corresponding Author |
Yu Wang, MD, Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Yuexiu District, Guangzhou 510060, Guangdong Province, China. wangyu@sysucc.org.cn |
| Key Words |
Primary intestinal diffuse large B-cell lymphoma; Prognostic model; SEER; External validation; Risk factors |
| Core Tip |
This study identifies intestinal laterality (left vs right of the splenic flexure) as a key, previously overlooked prognostic factor in primary intestinal diffuse large B-cell lymphoma (DLBCL): Left-sided disease confers worse overall survival, whereas right-sided disease even surpasses intra-abdominal nodal DLBCL. Leveraging SEER (n = 3832) and an external validation cohort (n = 107), we built and validated a simple nomogram (age, stage, chemotherapy, surgery, laterality) that delivered higher discrimination than the international prognostic index. The model operationalizes tumor location for individualized prognosis and may inform risk-adapted clinical decisions. |
| Citation |
Zeng RX, Wang CQ, Yang H, Sun P, Liu PP, Wei LC, Chen TT, Wang Z, Huang H, Li ZM, Tian XP, Wang Y. Anatomical laterality of primary intestinal diffuse large B-cell lymphoma independently stratifies survival: New prognostic nomogram incorporating tumor location. World J Gastroenterol 2025; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
