Publication Name	World Journal of Gastroenterology
Manuscript ID	115416
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Dual cut-offs and beyond: Expanding the role of transient elastography in primary biliary cholangitis
Manuscript Source	Invited Manuscript
All Author List	Vasily Isakov and Alexei Goncharov
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Higher Education of the Russian Federation No. FGMF-2025-0003
Corresponding Author	Vasily Isakov, AGAF, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Federal Research Center of Nutrition, Biotechnology and Food Safety, 21 Kashirskoe Shosse, Moscow 115446, Russia. vasily.isakov@gmail.com
Key Words	Primary biliary cholangitis; Vibration-controlled transient elastography; Liver stiffness measurement; Prognostic value; Liver fibrosis staging
Core Tip	Transient elastography is transforming the fibrosis evaluation in primary biliary cholangitis (PBC). The dual cut-offs proposed by Chen et al (≤ 10 kPa and > 14.5 kPa) achieved excellent diagnostic accuracy and could eliminate the need for biopsy in most patients. However, interpretation requires attention to confounders such as cholestasiss, inflammation, and overlap syndromes. Standardized protocols, cross-modality validation, and integration with clinical scores will define the next frontier of precision staging for PBC.
Citation	Isakov V, Goncharov A. Dual cut-offs and beyond: Expanding the role of transient elastography in primary biliary cholangitis. World J Gastroenterol 2026; In press

Received	2025-10-16 12:54
Peer-Review Started	2025-10-16 12:54
First Decision by Editorial Office Director	2025-11-26 09:30
Return for Revision	2025-11-26 09:30
Revised	2025-11-30 10:51
Publication Fee Transferred
Second Decision by Editor	2026-01-07 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-07 08:48
Articles in Press	2026-01-07 08:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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