Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115417
Country	Greece

Category	Surgery
Manuscript Type	Minireviews
Article Title	Somatostatin and its analogs in the management of postoperative pancreatic fistulas: A comprehensive review
Manuscript Source	Invited Manuscript
All Author List	Lydia Lazaridou, Alexandra Dimaki, Kalliopi Vakalou, Vasilios Zervas, Panagiotis Papadopoulos, Konstantinos E Koumarelas and Grigorios Christodoulidis
Funding Agency and Grant Number
Corresponding Author	Grigorios Christodoulidis, MD, PhD, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Thessalia, Greece. gregsurg@yahoo.gr
Key Words	Postoperative pancreatic fistula; Pancreatic surgery; Pancreaticoduodenectomy; Distal pancreatectomy; Somatostatin; Somatostatin analogues; Octreotide; Lanreotide; Pasireotide; Prophylaxis
Core Tip	Postoperative pancreatic fistula (POPF) remains a major challenge in pancreatic surgery. Somatostatin and its analogs reduce exocrine secretion and have been widely evaluated for POPF prevention and management. Evidence from recent meta-analyses and randomized trials suggests that while these agents significantly lower POPF incidence, their effect on mortality is minimal. Current research focuses on patient risk stratification and long-acting depot formulations, such as preoperative lanreotide, to enhance compliance and cost-effectiveness. A tailored, risk-adjusted prophylaxis strategy may represent the future standard of care.
Citation	Lazaridou L, Dimaki A, Vakalou K, Zervas V, Papadopoulos P, Koumarelas KE, Christodoulidis G. Somatostatin and its analogs in the management of postoperative pancreatic fistulas: A comprehensive review. World J Gastrointest Surg 2025; In press

Received	2025-10-16 12:59
Peer-Review Started	2025-10-16 13:00
First Decision by Editorial Office Director	2025-11-05 05:59
Return for Revision	2025-11-05 05:59
Revised	2025-11-18 20:52
Publication Fee Transferred
Second Decision by Editor	2025-12-17 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 11:55
Articles in Press	2025-12-17 11:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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