Publication Name	World Journal of Diabetes
Manuscript ID	115437
Country	China

Category	Urology & Nephrology
Manuscript Type	Basic Study
Article Title	EP300 drives renal fibrosis in diabetic nephropathy via histone acetyltransferase-mediated nephrocystin-4 expression
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Si, Yao Dai, Guo-Ping Hu, Qiang Zhang, Fang Lv and Qiu Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Anhui Province Traditional Chinese Medicine Inheritance and Innovation Research Project No. 2024CCCX142
Corresponding Author	Qiu Zhang, MD, PhD, Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, No. 136 Jixi Road, Hefei 230022, Anhui Province, China. zhangqiu@ahmu.edu.cn
Key Words	EP300/nephrocystin-4; Diabetic nephropathy; Fibrosis; 27th lysine position of histone H3 modification; Targeted intervention
Core Tip	Renal fibrosis is a key pathological process driving diabetic nephropathy progression, yet its epigenetic regulation remains unclear. This study identifies EP300 as a histone acetyltransferase that activates nephrocystin-4 transcription through 27th lysine position of histone H3 modification, promoting renal fibrosis. Inhibition of the EP300-nephrocystin-4 axis alleviates fibrotic injury and improves renal function in diabetic mice, providing new mechanistic insight and a potential therapeutic target for diabetic nephropathy.
Citation	Si W, Dai Y, Hu GP, Zhang Q, Lv F, Zhang Q. EP300 drives renal fibrosis in diabetic nephropathy via histone acetyltransferase-mediated nephrocystin-4 expression. World J Diabetes 2026; In press

Received	2025-10-16 12:08
Peer-Review Started	2025-10-17 05:39
First Decision by Editorial Office Director	2025-11-26 08:21
Return for Revision	2025-11-26 08:21
Revised	2025-12-03 07:09
Publication Fee Transferred	2025-12-04 12:25
Second Decision by Editor	2026-01-14 02:50
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-21 08:18
Articles in Press	2026-01-21 08:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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