Publication Name	World Journal of Gastroenterology
Manuscript ID	115439
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Growth differentiation factor 15 - a new molecular target in inflammatory bowel disease: Progress and challenges
Manuscript Source	Invited Manuscript
All Author List	Jia Yang, Ya-Ting Pan and Hong-Zhu Wen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82274285
Corresponding Author	Hong-Zhu Wen, Department of Gastroenterology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725 Wanping South Road, Xuhui District, Shanghai 200032, China. ellawhz@sina.com
Key Words	Growth differentiation factor 15; Double-edged mediator; Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease
Core Tip	The study by Ruiz-Malagón et al represents an important step toward elucidating the pathogenesis of inflammatory bowel disease, suggesting that growth differentiation factor 15 (GDF15) may contribute to disease development. GDF15 functions as a context-dependent mediator with both protective and pathogenic effects, and clarifying this duality remains a key objective for translational research. Current findings, derived largely from small observational cohorts, should be interpreted with caution and require validation in larger, independent populations. Ultimately, well-designed randomized controlled trials will be essential to establish more definitive evidence.
Citation	Yang J, Pan YT, Wen HZ. Growth differentiation factor 15 - a new molecular target in inflammatory bowel disease: Progress and challenges. World J Gastroenterol 2025; In press

Received	2025-10-17 13:16
Peer-Review Started	2025-10-17 13:17
First Decision by Editorial Office Director	2025-11-05 09:23
Return for Revision	2025-11-05 09:23
Revised	2025-11-17 10:09
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 07:32
Articles in Press	2025-12-15 07:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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