Publication Name	World Journal of Gastroenterology
Manuscript ID	115440
Country	China

Category	Oncology
Manuscript Type	Editorial
Article Title	Risk stratification of gastric neuroendocrine tumors in autoimmune gastritis: Evaluating the clinical value of an integrated clinical-endoscopic model
Manuscript Source	Invited Manuscript
All Author List	Qing-Qing Yu
Funding Agency and Grant Number
Corresponding Author	Qing-Qing Yu, Professor, Clinical Research Center, Jining No. 1 People's Hospital, No. 6 Jiankang Road, Jining 272000, Shandong Province, China. yuqingqing_lucky@163.com
Key Words	Gastric neuroendocrine tumors; Autoimmune gastritis; Integrated model; Endoscope; Integrated model
Core Tip	Autoimmune gastritis induces gastric neuroendocrine tumors through a multistep process involving oxyntic mucosal destruction, hypergastrinemia, and enterochromaffin-like cell proliferation. Integrated clinical-endoscopic models utilizing machine learning (e.g., Boruta algorithm) outperform single-parameter approaches, with key predictors including atrophy severity, gastrin levels, and Helicobacter pylori history. These models enable personalized risk-adapted surveillance, inform vitamin B12 chemoprevention, and improve prognostic stratification by incorporating endoscopic and proliferative indices. Current limitations include single-center bias and incomplete molecular integration; future development requires multicenter validation and multimodal biomarkers.
Citation	Yu QQ. Risk stratification of gastric neuroendocrine tumors in autoimmune gastritis: Evaluating the clinical value of an integrated clinical-endoscopic model. World J Gastroenterol 2026; In press

Received	2025-10-20 02:00
Peer-Review Started	2025-10-20 02:00
First Decision by Editorial Office Director	2025-11-21 09:59
Return for Revision	2025-11-21 09:59
Revised	2025-12-04 08:37
Publication Fee Transferred
Second Decision by Editor	2026-01-28 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-28 07:41
Articles in Press	2026-01-28 07:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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