Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115444
Country	Türkiye

Category	Surgery
Manuscript Type	Prospective Study
Article Title	Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study
Manuscript Source	Unsolicited Manuscript
All Author List	Gizem Güneş, Esra Fırat Oğuz, Ilgaz Kayılıoğlu and Tolga Dinç
Funding Agency and Grant Number	Funding Agency Grant Number University of Health Sciences No. 2021/144
Corresponding Author	Ilgaz Kayılıoğlu, Associate Professor, MD, Department of General Surgery, Izan Private Health Hospital, Ahmetçavuş-Hayıtlı Mah. Atatürk Bul. No. 21, Milas, Muğla 48200, Türkiye. kayilioglu@yahoo.com
Key Words	Adenocarcinoma; Biomarkers; Tumor; Colorectal neoplasms; Early detection of cancer; Interleukin-8
Core Tip	This prospective study demonstrates that serum interleukin-8 (IL-8) levels were significantly elevated in colon adenocarcinoma patients. Although diagnostic accuracy was moderate (area under the curve = 0.68), IL-8 remained an independent predictor. Prior evidence links IL-8 to survival and treatment response, suggesting diagnostic and prognostic utility. Larger multicenter studies are warranted to confirm and explore therapeutic implications.
Citation	Güneş G, Fırat Oğuz E, Kayılıoğlu I, Dinç T. Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study. World J Gastrointest Surg 2025; In press

Received	2025-10-20 09:29
Peer-Review Started	2025-10-20 09:29
To Make the First Decision
Return for Revision	2025-10-31 07:45
Revised	2025-11-05 07:58
Second Decision	2025-11-21 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 08:50
Articles in Press	2025-11-21 08:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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