Publication Name	World Journal of Hepatology
Manuscript ID	115475
Country	China

Category	Medicine, General & Internal
Manuscript Type	Retrospective Study
Article Title	Metabolic dysfunction-associated steatotic liver disease mediates the relationship between helicobacter pylori infection and colorectal adenoma risk
Manuscript Source	Invited Manuscript
All Author List	Zhao-Bei Cai, Bin-Bin Su, Pan-Yang Shi, Sheng-Shu Wang, Hui Shi and Qian-Qian Chen
Funding Agency and Grant Number
Corresponding Author	Qian-Qian Chen, Associate Chief Physician, Associate Professor, MD, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese PLA General Hospital, No.28 Fuxing Road, Haidian District, Beijing 100853, China. qian_qian_chen@163.com
Key Words	Colorectal adenomas; Helicobacter pylori infection; Metabolic dysfunction-associated steatotic liver disease; Interaction; Mediation
Core Tip	This study identifies both Helicobacter pylori (H. pylori) infection and metabolic dysfunction-associated steatotic liver disease (MASLD) as independent risk factors for colorectal adenoma. No interaction was found between them, but MASLD mediated the infection-adenoma risk relationship. These results support enhanced screening for colorectal adenoma in individuals with H. pylori infection and MASLD.
Citation	Cai ZB, Su BB, Shi PY, Wang SS, Shi H, Chen QQ. Metabolic dysfunction-associated steatotic liver disease mediates the relationship between helicobacter pylori infection and colorectal adenoma risk. World J Hepatol 2026; In press

Received	2025-10-31 06:12
Peer-Review Started	2025-10-31 06:12
First Decision by Editorial Office Director	2025-12-03 10:03
Return for Revision	2025-12-03 10:03
Revised	2025-12-15 15:31
Publication Fee Transferred
Second Decision by Editor	2026-01-20 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-20 07:50
Articles in Press	2026-01-20 07:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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