Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	115487
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Diagnostic challenges and multidisciplinary management of primary adenosquamous carcinoma of the liver: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Rui-Biao Fu and Xiao-Feng Dong
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82160589 Guangxi Science and Technology Major Project GuikeAA23073013
Corresponding Author	Xiao-Feng Dong, PhD, Department of Hepatobiliary, Pancreatic and Spleen Surgery, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous Region, No. 6 Taoyuan Road, Qingxiu District, Nanning 530012, Guangxi Zhuang Autonomous Region, China. xfdong@gxams.org.cn
Key Words	Primary adenosquamous carcinoma; Liver; Diagnosis; Clinical outcome; Case report
Core Tip	In this report, we present a case of primary hepatic adenosquamous carcinoma that was initially misdiagnosed as a liver abscess. We highlight how markedly elevated carcinoembryonic antigen and cancer antigen 19-9 prompted further investigation, leading to surgical resection and pathologic confirmation. Importantly, we demonstrate promising short-term outcomes using a multimodal approach combining radical surgery with adjuvant lenvatinib and envafolimab. Our experience underscores the necessity of histopathologic diagnosis for adenosquamous carcinoma and suggests that aggressive combined modality therapy may improve survival in this highly aggressive malignancy.
Citation	Fu RB, Dong XF. Diagnostic challenges and multidisciplinary management of primary adenosquamous carcinoma of the liver: A case report and review of literature. World J Gastrointest Surg 2026; In press

Received	2025-10-20 10:01
Peer-Review Started	2025-10-20 10:01
First Decision by Editorial Office Director	2025-10-28 10:31
Return for Revision	2025-10-29 01:13
Revised	2025-11-06 16:40
Publication Fee Transferred	2025-11-09 15:27
Second Decision by Editor	2026-02-05 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-05 04:50
Articles in Press	2026-02-05 04:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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