Publication Name	World Journal of Cardiology
Manuscript ID	115494
Country	South Korea

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Letter to the Editor
Article Title	APOE, SLCO1B1, and LPA polymorphisms in a unique Chinese population
Manuscript Source	Unsolicited Manuscript
All Author List	Haewon Byeon
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea RS-2023-00237287
Corresponding Author	Haewon Byeon, Associate Professor, Director, PhD, Worker's Care & Digital Health Lab, Department of Future Technology, Korea University of Technology and Education, 1600, Chungjeol-ro, Cheonan 31253, South Korea. bhwpuma@naver.com
Key Words	APOE ε4; LPA KIV-2; Coronary heart disease; Teochew population; Gene-environment interactions
Core Tip	The study by Xu et al explored the association of APOE, SLCO1B1, and LPA KIV-2 polymorphisms with coronary heart disease (CHD) in the unique Teochew population. Key findings indicate that the APOE ε2 allele and a higher LPA KIV-2 copy number are associated with a reduced risk of CHD. Conversely, and notably, the well-known risk allele APOE ε4 and polymorphisms in SLCO1B1 (related to statin metabolism) showed no significant association. This highlights the population-specific nature of genetic risk factors for CHD. While valuable for regional genetic insights, the study’s retrospective design and modest control group size warrant cautious interpretation and call for larger, prospective validation studies.
Citation	Byeon H. APOE, SLCO1B1, and LPA polymorphisms in a unique Chinese population. World J Cardiol 2026; In press

Received	2025-10-20 09:06
Peer-Review Started	2025-10-20 09:06
First Decision by Editorial Office Director	2025-11-04 08:02
Return for Revision	2025-11-04 08:02
Revised	2025-11-05 12:20
Publication Fee Transferred
Second Decision by Editor	2026-01-09 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 07:09
Articles in Press	2026-01-09 07:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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